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Biochemical Evaluation of cells from these mutants exposed that Lyn is critical in developing ITIM-dependent inhibitory signaling and for activation of certain protein tyrosine phosphatases within just myeloid cells.[13]
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Mice that expressed a hyperactive Lyn allele have been tumor totally free and exhibited no propensity toward hematological malignancy. These mice have lessened figures of standard B lymphocytes, down-regulated area immunoglobulin M and costimulatory molecules, and elevated figures of B1a B cells.
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